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What effect do antibiotics have on immunity? Antibiotics have an indirect effect on the body's ability to cope with the infection. This happens with improper use (short course) or excessive use of antibiotics (longer than necessary, or not according to indications, for example, for the treatment of SARS). Antibiotics canadaonpharm.com kill or block the multiplication of susceptible bacteria. The rest remain alive and continue to multiply. They are easily transmitted from person to person, and all infections caused by resistant bacteria are no longer amenable to treatment with previously used antibiotics. Therapy to pick up is very, very difficult.